Groundbreaking research organizes and analyzes prior research on cannabis’ effect on healthy subjects in an elegant meta-analysis of neuroimaging and cognitive function studies.
Cannabis contains various molecules which bind to receptors in the brain, aptly called “cannabinoid receptors”. Familiar ligands (which bind to those receptors) include THC (tetrahydrocannabinol) and CBD (cannabidiol), binding to receptors such as the CB1 and CB2 receptors with various downstream functions on the brain. The primary neurotransmitter involved in innate (endogenous) cannabinoid activity is “anandamide”, a unique “fatty acid neurotransmitter” whose name means “joy”, “bliss” or “delight” in Sanskrit and related ancient tongues. This neurotransmitter system has only relatively recently been investigated in greater detail, and the basic biology is fairly well worked out (e.g. Kovacovic & Somanathan, 2014), improving understanding of therapeutic… Read More